|ESTP Thesis Award 2018 in Toxicological Pathology
The European Society of Toxicologic Pathology (ESTP) offers every second year an award for a thesis in toxicological pathology.
Winners in 2018:
- Dr. Sohvi Blatter
Dr. Blatter is awarded EUR 2,000 for her thesis entitled "Targeting drug tolerance of residual Brca1-mutated mouse mammary tumors".
In her thesis Dr. Blatter has given a very concise review of the current state of research of residual disease in cancer. The experimental part contasined a vast array of techniques and focused on the following points: In the first experimental part, markers for residual cancer cells were established and several therapeutic agents were tested for their effectiveness in Brca1-/-;p53-/- mammary tumors orthotopically transplanted into wild-type FVB/N mice. Additionally, the toxic effects of Poly (ADP ribose)-polymerase (PARP) inhibitors on cancer cells with mutations in homologous recombination were investigated. In the last part, she showed that the tumors create an immunosuppressive environment and investigated the effectiveness of immunotherapy.
This thesis is an important contribution to the elucidation of residual disease in cancer and points to potential therapeutic targets.
Sohvi Blatter, Targeting drug tolerance of residual Brca1-mutated mouse mammary tumors 2018
- Dr. David Højland Ipsen
Dr. Ipsen is awarded EUR 1,500 for his thesis entitled "The guinea pig as a model for dyslipidemia and non-alcoholic fatty liver disease".
Dr. Ipsen has created a guinea pig model for dyslipidemia and investigated the influence of different diet compositions as well as treatment options on the development of the disease. Three very informative reviews on the pathogenesis of dyslipidemia and fatty liver disease complement the thesis.
This thesis introduces and characterizes an interesting animal model for dyslipidemia and fatty liver disease.
David Højland Ipsen, The guinea pig as a model for dyslipidemia and non-alcoholic fatty liver disease 2017
- Dr. Nicole Jungwirth
Dr. Jungwirth is awarded EUR 1,000 for her thesis entitled "Investigation of the modulatory effects of mesenchymal stem cells for support of remyelination in the CNS".
In her work Dr. Jungwirth has investigated the influence of canine, human and murine stem cells on remyelination in a cuprizone induced mouse model of demyelination.
This thesis showed no influence of mesenchymal stem cells on the process of remyelination and an immune response against human and canine mesenchymal stem cells.
Nicole Jungwirth, Investigation of the modulatory effects of mesenchymal stem cells for support of remyelination in the CNS 2016
Copenhagen, September 13, 2018
|Dr. Sibylle Gröters
Chairman of the ESTP
|Heike Marxfeld, PhD
Chair of the ESTP award committee