European Society of Toxicologic Pathology (ESTP)
    European Society of Toxicologic Pathology
Guess What! - Solution Overview
Case 1
Case #1

Species/Strain: Wistar Rat
Organ:Brown Fat
Diagnosis:Angiomatous hamartoma
INHAND:Hamartoma
Case 2
Case #2

Species/Strain: Wistar Rat
Organ:Lung/Bronchus
Diagnosis:Focal epithelial hyperplasia of neuroendocrine cells
INHAND:Hyperplasia, neuroendocrine cell
Case 3
Case #3

Species/Strain: CD1 Mouse
Organ:Spleen
Diagnosis:Hyperplasia of interdigitating dendritic cells
INHAND:Cellularity increased, macrophage
Case 4
Case #4

Species/Strain: Cynomolgus Monkey
Organ:Uterus
Diagnosis:Spontaneous epithelial plaques of the uterus in a non-pregnant monkey
INHAND:Epithelial plaque
Case 5
Case #5

Species/Strain: Wistar Rat
Organ:Eye
Diagnosis:Retinal Gliosis
INHAND:Glial cells, increased number
Case 6
Case #6

Species/Strain: Wistar Rat
Organ:Ovary
Diagnosis:Tubulostromal hyperplasia
INHAND:Hyperplasia, tubulostromal
Case 7
Case #7

Species/Strain: Wistar Rat
Organ:Thyroid
Diagnosis:Follicular cell carcinoma and C-cell adenoma
INHAND:Carcinoma, follicular cell and Carcinoma, c-cell
Case 8
Case #8

Species/Strain: Syrian Hamster
Organ:Skin/Subcutis
Diagnosis:(Female) flank organ
Case 9
Case #9

Species/Strain: Sprague Dawley Rat
Organ:Tail
Diagnosis:Reactive proliferative change of vascular elements around the mid-ventral coccygeal artery due to impairment of venous return after intravenous injection
Case 10
Case #10

Species/Strain: Wistar Rat
Organ:Oral Cavity
Diagnosis:Unilateral Fordyce's granules of the upper molar gingiva in female Wistar rat
INHAND:Ectopic sebacous gland
Case 11
Case #11

Species/Strain: Wistar Rat
Organ:Joint
Diagnosis:Fibrosis and chondroid metaplasia of the synovialis in response to thrombosis of (sub)synovial vasculatur
INHAND:Degenerative joint disease
Case 12
Case #12

Species/Strain: Cynomolgus Monkey
Organ:Lung/Bronchus
Diagnosis:Cystic Echinococcosis, caused by Echinococcus granulosus
INHAND:Parasite
Case 13
Case #13

Species/Strain: Wistar Rat
Organ:Thymus
Diagnosis:Benign schwannoma
INHAND:Schwannoma, benign
Case 14
Case #14

Species/Strain: Cynomolgus Monkey
Organ:Ovary
Diagnosis:Mature ovarian teratoma
INHAND:Teratoma, benign
Case 15
Case #15

Species/Strain: Marmoset
Organ:Kidney
Diagnosis:Severe, diffuse mesangioproliferative glomerulonephritis (MPGN) with severe chronic tubulointerstial inflammation due to immune complex glomerulonephritis (ICGN); IgM/IgA-Nepropathy
INHAND:Glomerulonephritis, Interstitial nephritis
Case 16
Case #16

Species/Strain: Cynomolgus Monkey
Organ:Ovary
Diagnosis:Unilateral Brenner tumor
INHAND:Ovarian surface epithelial tumor
Case 17
Case #17

Species/Strain: NZW Rabbit
Organ:Male Accessory Glands
Diagnosis:Multifocal basal cell hyperplasia of the prostate and multifocal basal cell hyperplasia with squamous metaplasia of the vesicular gland
INHAND:Hyperplasia, basal cell and Metaplasia, squamous
Case 18
Case #18

Species/Strain: Wistar Rat
Organ:Thoracic Cavity
Diagnosis:Mediastinum: extragenital yolk sac carcinoma
INHAND:Carcinoma, yolk sac
Case 19
Case #19

Species/Strain: Wistar Rat
Organ:Ear
Diagnosis:Auricular chondritis (auricular chondropathy)
INHAND:Inflammation, auricular cartilage
Case 20
Case #20

Species/Strain: Wistar Rat
Organ:Skin/Subcutis
Diagnosis:Tumor, hair follicle, benign; pilomatricoma type
INHAND:Tumor, hair follicle, benign; pilomatricoma type
Case 21
Case #21

Species/Strain: Cynomolgus Monkey
Organ:Testis
Diagnosis:Testicular fibrous hypoplasia
INHAND:Increased, stromal collagen, (testis or rete testis)
Case 22
Case #22

Species/Strain: Wistar Rat
Organ:Bone
Diagnosis:Granulomatous inflammatory process with abundant black (Indian ink) pigment
INHAND:Pigment, macrophage and Inflammation, granulomatous
Case 23
Case #23

Species/Strain: TG Mouse
Organ:Bone
Diagnosis:Osteogenesis imperfecta
INHAND:Bone, decreased, trabecula and/or cortex
Case 24
Case #24

Species/Strain: Wistar Rat
Organ:Thymus
Diagnosis: Conventional histopathology:
Atrophy, cortex; Hyperplasia, lymphoid, medulla; Loss of corticomedullary distinction
Enhanced histopathology:
Lymphocytes decreased, cortex; lymphocytes increased, T-lymphocytes, medulla; Loss of corticomedullary distinction
INHAND:see main diagnosis/already according to INHAND
Case 25
Case #25

Species/Strain: CD1 Mouse
Organ:Adrenal Glands
Diagnosis:Multiple age-related (proliferative) adrenal findings
INHAND:see main diagnosis/already according to INHAND
Case 26
Case #26

Species/Strain: Zebrafish
Organ:Ovary
Diagnosis:Severe multifocal locally extensive atrophy of ovigerous lamellae
Case 27
Case #27

Species/Strain: Rabbit (Himalayan)
Organ:Brain/Cerebral Meninx
Diagnosis:Inflammation, granulomatous and Infiltrate, inflammatory cell, perivascular ("Encephalitozoonosis")
INHAND:Not yet published – currently under "Parasite"