 | |
| Digital slide(s): |
Case 3a
Case 3b |
| Species / breed: |
Mouse, CB6F1/Jic-TgrasH2@Tac hemizygous |
| Sex: |
Female |
| Age: |
10 weeks (at start of dosing). |
| Study type: |
26-week oral (dietary) carcinogenicity study in CB6F1-rasH2 mice |
| Treatment: |
Positive control (MNU) |
| Clinical findings: |
0410091_233F_25: Skin/fur, Ulcer (neck). Terminal sacrifice on test day 154; 0410091_244F_25: Mass (inguinal region left). Sacrificed for human reason test day 106 |
| Organ(s): |
Skin |
| Gross finding(s): |
0410091_233F_25: Correlate to clinical observation; 0410091_244F_25: Single mass in the inguinal region left, approximately 3 cm long and 2 cm wide, nodular, cut surface: nodular. Correlate to clinical observation |
| Staining: |
H&E |
