ESTP Congress 2006: Case No 6

European Society of Toxicologic Pathology


Digital slide(s):	Case 6-1: Vehicle male, Anti-a2u-globulin IHC Case 6-2: Vehicle male, Anti-a2u-globulin IHC Case 6-3: Treated male, Anti-a2u-globulin IHC Case 6-4: Treated male, Anti-a2u-globulin IHC
Species / breed:	Rat, Sprague-Dawley
Sex:	Male
Age:	Approx. 12 weeks
Study type:	Method validation
Treatment:	d-limonene (300 mg/kg, once daily during 2 weeks)
Clinical findings:	Not applicable
Organ(s):	Kidney
Gross finding(s):	Mean increase in kidney weight from treated group: 12% when compared to vehicle group
Staining:	H&E; IHC method (anti-a2u-globulin monoclonal antibody (R&D Systems MAB586) with or without microwave pre-treatment (depending on length of formalin fixation)

case index | << previous case | next case >>