 | |
| Digital slide(s): |
Case 3-1: Eye
Case 3-2: Eye |
| Species / breed: |
Rat, Wistar |
| Sex: |
Male |
| Age: |
About 2 year old |
| Study type: |
Carcinogenicity study |
| Treatment: |
HPPDase inhibitors
Tissue samples from different treated rats at high dose and sacrificed at or close to the end of the study. |
| Clinical findings: |
At the 6 month, 1 and 2 year ophthalmoscopy examination, treatment-related findings consisted of corneal opacity, neovascularisation, edema of the cornea and "snow flake-like" corneal opacity in both sexes. |
| Organ(s): |
Eye |
| Gross finding(s): |
Ocular opacity |
| Staining: |
H&E |
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