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| Digital slide: |
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| Species: |
Cynomolgus monkey |
| Strain/breeder: |
Mauritius |
| Sex: |
Male |
| Age: |
4 years |
| Study type: |
266 days treatment |
| Treatment: |
ABI793 (anti-human CD154 monoclonal antibodies) 8 x 20 mg/kg i.v. |
| Animal status: |
108 days post-transplantation (kidney allograft) |
| Clinical findings: |
Serum creatinine: 472 µmol/L; serum urea 16.5 mmol/L |
| Organ(s): |
Kidney allograft |
Gross
finding(s): |
Kidney enlarged; Cut surface: grey-white discolored |
| Staining: |
H&E |
| Literature: |
| Schuler W, Bigaud M, Brinkmann V, Di Padova F, Geisse S, Gram H, Hungerford V, Kleuser B, Kristofic C, Menninger K, Tees R, Wieczorek G, Wilt C, Wioland C, Zurini M.: Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantation. Transplantation. 2004, 77: 717-726 |
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