European Society of Toxicologic Pathology (ESTP)
    European Society of Toxicologic Pathology
ESTP Congress 2004: Case No 7
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Digital slide: Case 7-1
Case 7-2
Species: Rat
Strain/breeder: Wistar (CrLGlxBrlHan:WI)
Sex: Male
Age: Approx. 8 weeks
Study type: 14-day gavage study
Treatment: VEGFR-antagonist
Animal status: No abnormalities detected
Clinical findings: None
Organ(s): Kidneys
Gross
finding(s):
none
Staining: H&E (case 7/1), PAS (case 7/2)
Literature:
H.F. Dvorak (2003): How tumours make bad blood vessels and stroma. Am.J.Pathol. 162, 1747 - 1757
H.F. Dvorak (2002): Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J.Clin.Oncol. 20, 4368 – 4380
Feng D, Nagy J, Hipp J, Dvorak H, Dvorak A and. (1996) Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine, and serotonin. J Exp Med 183: 1981–198

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