Monday, September 17
|
Topic: Predictive toxicology
(Chair: Friedlieb Pfannkuch)
|
| 8:30-10:30 |
Toxicopathology and "omics" of PPARs
Session chairs: Hugh E. Black / Christopher J. Powell
Structure and Function of the peroxisome
Hugh E. Black
Comparative effects of different types of PPAR agonist on histopathology and gene expression changes in epididymal and subcutaneous adipose tissue
NN
The comparative effects of different alpha/gamma PPAR agonists on human and animal urothelium
Jenny Southgate
PPAR-g: Bridging the gap between morphology and genomics
Jeffery A. Engelhardt
|
| 10:30-11:00 |
Coffee break |
| 11:00-12:00 |
RITA presentation and Case presentations |
| 12:00-13:30 |
Lunch |
| 13:30-15:00 |
Predictive toxicology - Biomarker development
Session chairs: Doug Wolf / Friedlieb Pfannkuch
US FDA and US EPA voluntary submission of genomic data guidance
Doug Wolf
PredTox Project of EU Framework Programme 6
Friedlieb Pfannkuch
Challenge of integrating "omics" results
Laura Suter-Dick
Application of digital slide scanning and microarry technology for integration of toxicological pathology and biomarker development
William Gallagher
From "omics" to mechanism- based markers of toxicity
Angela Mally
|
| 15:00-15:30 |
Coffee break |
| 15:30-17:30 |
Basic mechanisms and morphology of hepatotoxicity
Session chairs: Stephan Krähenbühl / Jack Uetrecht
Morphology of drug induced hepatotoxicity - classical example
Luigi Terracciano
Idiosyncratic hepatotoxicity: mechanisms and predictability
Jack Uetrecht
Mitochondrial hepatic toxicity
Stephan Krähenbühl
Case presentation
Lars Mecklenburg
|
| 18:00-19:00 |
Zeiss Satellite Symposium: "New ways of image analysis in pathology" |
Tuesday, September 18
|
Topic: Carcinogenicity assessment - alternative approaches
(Chair: Paul-Georg Germann)
|
| 8:30-10:00 |
Experience with transgenic models
Session chairs: H. Tsuda / Paul-Georg Germann
Update of FDA experience with risk assessment using transgenic animal models
D. Jacobson Kram
Possible risk assessment using human ras gene transgenic rat
H. Tsuda
|
| 10:00-10:30 |
Coffee break |
| 10:30-12:00 |
Non-transgenic whole animal models - real alternatives?
Session chairs: S. Cohen / T. Shirai
An enhanced 13 week bioassay: An alternative to the two-year bioassay to screen for human carcinogenesis
S. Cohen
The Syrian golden hamster: Recent application in drug development and registration
Heinrich Ernst, Paul-Georg Germann
|
| 12:00-13:30 |
Lunch, Poster Session
During lunch break there will be a forum discussion forum on qualification of Toxicologic Pathologist (see EMEA carcinogenicity guideline) |
| 13:30-15:00 |
In vitro / In silico tools: Room for improved predictivity and relevance of toxicological pathology?
Session chairs: J. Evans / T. Shirai
In silico assessment of carcinogenic potential
S. Glowienke
Alternative in vitro methods for mutagenicity and carcinogenicity
T. Hartung
Predictive toxicogenomics for chemical carcinogenic potential in rat liver
T. Shirai
|
| 15:00-15:30 |
Coffee break |
| 15:30-16:45 |
Chronic risk assessment of monoclonals and biologicals
Session chairs: J. Sims / S. Cohen
EMEA view of preventing chronic risk from biologics
J.-W. van der Laan
Clinical long term risks of biologics: impact on drug development
J. Green or J. Clark
|
| 16:45-17:00 |
Case presentation |
| 17:00-19:00 |
ESTP Annual Assembly |
| 19:00 |
Congress dinner at the Basel Zoo |
Wednesday, September 19
|
Topic: Dermatopathology
(Chair: Barbara Lenz) |
| 8:30-9:30 |
Dermatopathology I
Introduction to dermatopathology
M. Suter / M. Welle
Pattern analysis: An approach to the diagnosis of histological skin changes
M. Welle |
| 9:30-10:00 |
Case presentations |
| 10:00-10:30 |
Coffee break |
| 10:30-12:00 |
Dermatopathology II
Epidermal homeostasis and disease including some examples of induced lesions
M. Suter / E. Mueller
The skin as target organ of allergic reactions to small molecular weight compounds
H. Merk |
| 12:00-13:30 |
Lunch, Poster Session |
| 13:30-14:15 |
Case presentations |
| 14:15-14:45 |
Dermatopathology III
Hair follicle tumors with special emphasis on those of lab animals
M. Goldschmidt
|
| 14:45-15:15 |
Coffee break |
| 15:15-15:45 |
Case presentations
|
| 15:45-16:00 |
Closing remarks |
